Nope. I don't think so.
There will always be a market for indie businesses. If you look at what the big brands are offering, it's the same thing as always, just dressed up for curly hair (e.g., black woman with an afro on bottle). There is nothing different they are doing except not using mineral oil (maybe) and not putting silicones (again, maybe).
I can bet that Darcy's, Oyin, QB and all the other afro type brands will still get business. There is something that indie businesses offer that big companies cannot.
Curly hair products from big companies have been around. We use these brands all the time, just some folks are now getting to notice.