I've never had a Droid phone before. I started with an iPhone 3g and stuck with iPhones. I also have a Mac that I sync to at home. My husband has a PC, though, and I don't think he's had any problems.
Gekko just switched from a string of Droid phones to an iPhone 5. She says she loves her iPhone but I don't know exactly what's better about it. Maybe she'll post when she's back online in a couple days.