According to Live Curly Live Free, Amodimethicone with Tricedeth-12 and Cetrimonium Chloride is only water dispersible in the bottle. Once it's on the hair it is not water soluble, though it does repel further deposits.

A note about amodimethicone: if you do an Internet search on amodimethicone, you will find quite a few sites that list amodimethicone as a silicone that is "slightly" soluble in water as long as two additional ingredients are included in the formulation:

Amodimethicone (and) Trideceth-12 (and) Cetrimonium Chloride (as a mixture in the bottle)

The assumption has always been that the inclusion of Trideceth-12 (a nonionic surfactant) and cetrimonium chloride (a cationic surfactant) render the amodimethicone, non-water soluble on its own, slightly soluble in water and it could be considered okay to use. Turns out that has been a completely incorrect assumption. What the Trideceth-12 and cetrimonium chloride do is render the amodimethicone dispersible in water. Once the amodimethicone is deposited onto the hair shaft and dries to a film, however, it is not water-soluble, will prevent moisture from getting into the hair shaft and will require a surfactant to remove.
CG since 11/2011
2c /3a F /Mii, low porosity

Autumn Products /Routine:
Clarifying: ACV rinses, Suave Professional Men Deep Clean Peppermint
Low Poo: Renpure Luxurious Argan Oil
Co-washes: VO5 Kiwi Lime Squeeze or Strawberries & Cream
RO: VO5 KLS or S&C, Cure Care
LI (if needed): VO5 S&C, VO5 KLS, Cure Care
Stylers: FSG, L'Oreal Studio Clean gel, Tresemme Flawless Curls Bouncy Curls gel
PT: IAGirl's as needed