According to Live Curly Live Free, Amodimethicone with Tricedeth-12 and Cetrimonium Chloride is only water dispersible in the bottle. Once it's on the hair it is not water soluble, though it does repel further deposits.

A note about amodimethicone: if you do an Internet search on amodimethicone, you will find quite a few sites that list amodimethicone as a silicone that is "slightly" soluble in water as long as two additional ingredients are included in the formulation:

Amodimethicone (and) Trideceth-12 (and) Cetrimonium Chloride (as a mixture in the bottle)

The assumption has always been that the inclusion of Trideceth-12 (a nonionic surfactant) and cetrimonium chloride (a cationic surfactant) render the amodimethicone, non-water soluble on its own, slightly soluble in water and it could be considered okay to use. Turns out that has been a completely incorrect assumption. What the Trideceth-12 and cetrimonium chloride do is render the amodimethicone dispersible in water. Once the amodimethicone is deposited onto the hair shaft and dries to a film, however, it is not water-soluble, will prevent moisture from getting into the hair shaft and will require a surfactant to remove.
CG since 11/2011
2c /3a F /Mii, low porosity

Winter Products /Routine:
Clarifying: Herbal Essences Tealightfully Clean
Low Poo: Renpure Luxurious Argan Oil
Co-washes: Suave Naturals Tropical Coconut or Daily Clarifying
RO:
Tresemme Expert Selection Perfectly (un)Done, Cure Care, Suave Tropical Coconut or Daily Clarifying
LI (if needed):
Tresemme Perfectly (un)Done, Renpure Brazilian Keratin Straightening (old formula), Cure Care
Stylers: HETT, AIF
PT: IAGirl's as needed