Totally!!! I got my Dad a 50" for Christmas and the picture still amazes me compared to my LCD.
Keep in mind though, that BluRay and HDMI make a HUGE difference. Stores will set up their pricier TVs with those so they look best. Easy to recreate that picture at home
The only down falls for a plasma are the glass screen. If you're a day time TV watcher, in a sunny room the glare can be annoying and if you have kids prone to throwing things, you can shatter the screen where the others may just scratch.