I just wanted to make sure that anyone reading this thread knows that while it can have significant side effects, many people do take it without problems beyond the typical dry skin and chapped lips. And as Chloe_s _Mom said, serious acne can be devastating emotionally. It's been such a wonder drug for so many kids I know. Often all you read online is bad. I wanted to let people know it can have really good, long-lasting results, too. If your quality of life is affected by your acne, and other medications aren't working, then it's worth consideration.