Definitely depends on the product. I use Prescriptives foundation because I can not find a drugstore version that is light enough for me (I am super pale, very fair skin). I also use their eyeshadow, blush and lipstick only because I really like the color, not because I think it is any better than the drugstore kind. I used drugstore versions for years but found I like the Prescriptives color array more. Mascara, lipliner, concealer, moisturizer, and eyeliner all come from the drugstore. Can't justify spending $18 or more on a liner when a $3 one works just as well.
Southern gals rock